The main objective of TM-Vector project is to develop a highly reproducible macromolecular edifice capable to function as a cooperative carrier for nucleic acids, characterized by the ability to be post-decorated with biochemical and / or pharmacologic active molecules, by virtue of dynamic processes of selective affinity of host-guest type.

According to the pragmatic goal of the project, the particular architecture of the carrying vector will offer three unique functional properties, representing our original contribution to the practice of nucleic acid vectorization: (i) the ability to target various cell receptors, by modifying the decorating molecule(s) attached using the “affinity-buttons”; as a consequence, different cancer cells may be attacked using the same type of molecular “tool”; (ii) the possibility to concomitantly vectorize several types of active molecules (e.g. nucleic acid molecules and pro-drug molecules); therefore, multiple biochemical and pharmacologic effects may be induced by administering a single type of carrier; (iii) the capacity to selectively attach molecules having neat different volumes and conformations, by simply (and even concomitantly) grafting PEG segments with different length, capped with cyclodextrin; thus, specialty biologics may be vectorized, in parallel with the nucleic acids, and, possibly, drugs.